1. Sleep is the most frequent question we ask when enquiring on psychological problem. Sleep a lot or having less sleep will always be indicator for psychological problem. Circadian rhythm is like an internal clock that works 24 hours a day.

2. Now we know if one has difficult sleeping, his circadian rhythm is altered. But which one comes first? (chicken-and-egg question)

3. Perhaps, agolomelatin has the answer. No bias please!

4. Since agomelatin activates kinases (which involve in intracellular signaling that took part in survival of newly formed neurons) and therefore influence clock gene expression and hence sleep-wake cycle, then it is safe to say that the circadian rhythm affect sleep not the other way round….

5. Wonder if I just learned a new thing or an old fact that has just been turn-around?