Recent advance in the genetic study of ADHD
Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. This study used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For the statistical approach, the researchers started with a linkage study based on large multigenerational families in a population isolate, followed by fine mapping of targeted regions using a family-based design. Family- and population-based association studies in five samples from disparate regions of the world were used for replication. Brain imaging studies were performed to evaluate gene function. The linkage study discovered a genome region harbored in the Latrophilin 3 gene (LPHN3).
In the world-wide samples (total n=6360, with 2627 ADHD cases and 2531 controls) statistical association of LPHN3 and ADHD was confirmed. Functional studies revealed that LPHN3 variants are expressed in key brain regions related to attention and activity, affect metabolism in neural circuits implicated in ADHD, and are associated with response to stimulant medication. Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD.
Authors: M Arcos-Burgos, M Jain, M T Acosta et. al.
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Published in: Molecular Psychiatry advance online publication 16 February 2010;doi: 10.1038/mp.2010.6
I see you are interested in statistical research. I have put one of the most comprehensive link lists for hundreds of thousands of statistical sources and indicators on my blog: Statistics Reference List. And what I find most fascinating is how data can be visualised nowadays with the graphical computing power of modern PCs, as in many of the dozens of examples in these Data Visualisation References. If you miss anything that I might be able to find for you or you yourself want to share a resource, please leave a comment.
First off I want to say awesome blog! I had a quick question that I’d like to ask if you don’t mind.
I was interested to find out how you center yourself and clear your head prior to writing.
I have had difficulty clearing my thoughts in getting my thoughts out.
I truly do enjoy writing but it just seems like the first 10 to 15 minutes tend to be lost just trying to
figure out how to begin. Any recommendations or hints?
TQ Barkha Atwal. I like writing. Often time constraint is the limitation. I find early morning is the best time to get fresh idea when the head is still empty and the thought is still fresh, as clear as crystal. Writers’ thought block can be overcome by simple brain storming based on category. Simply categorize your thought on what you want to write. Then, make some brain mapping on the content. Finally, elaborate on those ideas. Happy writing!
Just keep trying, my friend